| dc.description.abstract | Wound healing is a complex biological process in body, is achieved
through three phases: inflammation, proliferation, and remodeling. For healing a
wound successfully, all three phases must occur in the proper sequence and time
frame. During wound healing process, many factors can interfere with phases of
this process, thus causing impaired wound healing. So, the necessary of
treatment has good effect on cutaneous wound: anti-inflammatory, safety,
preventing infection, promoting wound healing in short time, leaving scar with a
low cost. In this study, we focus on the effect of oil-extracted Calophyllum
inophyllum L.(CIO) in the wound healing. We also compare the effect of CIO with
Betadine® and vehicle control. Recent skin models for wound healing are
examined in mice to examine the effect of topical treatment. Topical treatment
of CIO enhance the wound healing in the examined skin. Male mice, 8-10 weeksold,
weight mean 25.5±0.6g, healthy (n=6 in each group) were enrolled. The
topical treatments were assessed through day 1, day 7 and day 14. After
treatment, the scars or keloids were observed in each group by Hematoxylin and
Eosin staining. The wound areas were measured 2.5cm at day 1 and completely
recovery at day 7±2 with CIO but extent day 14±2 with control and at day 10±3
with Betadine®. After day 1, 7 and 14 of treatment of different formulations, the
mice were sacrificed and the spleen weight, length were taken to determine the
different among the different groups. Spleen indexes in the control group,
Betadine group and CIO group compare with normal group. Spleen indexes is
significant increase in comparing Betadine® group to normal group (P<0.0001 in
spleen length, P<0.05 in spleen weight) and vehicle control to normal (P<0.0001
in both spleen length and weight) while spleen indexes of CIO group (P=0.2132
in spleen length, P=0.7703 in spleen weight) has no significant. Base on this
study, topical treatment (CIO) has good effect on the rating wound healing or
the rate of wound area.
Key words:
Cutaneous wound
Wound healing
Oil-extracted Calophyllum inophyllum L.
Anti-inflammation | en_US |
