In silico structural basic analysis of linocin-m18 bacteriocin protein from burkholderia cenocepacia

Abstract

Encapsulin has been expected to be used as an effective and safe drug delivery approach. In this study, a computational approach was adopted to construct a monomer of linocin-M18 bacteriocin protein from Burkholderia cenocepacia which were expected to have high structural similarity with encapsulin. Different bioinformactics tools were used to construct a model by homology modeling, analyzed for statistics of structural appropriateness and characteristics. At the results, this study created a structure that satisfied in many aspects. Besides, it shows interesting traits of flexible loop and error-prone tail. The results also suggested a few drugs likely to be interact and packed into the icosahedral model. From these initial results, further studies on linocin-M18 bacteriocin structure should be conducted computationally and experimentally to prove and develop a novel material for drug transportation. Keywords: Encapsulin Bioinformatics Homology modelling