| dc.description.abstract | In this study, tea tree (Melaleuca alternifolia), betel (Piper betle L.) were used as
plant materials to create gel formulations with different concentrations to evaluate
the antibacterial and antioxidant activity. Moreover, aloe vera was contributed to
enhancing moisture and healing properties. Extraction factors such as temperature,
period, solvents, etc., affected the extraction yield of sample. The extraction yield of
tea tree is 1.47 ± 0.15% and betel is 0.17 ± 0.03%. The GC-MS results indicated
that chemical composition of each plant was affected by different locations,
environmental factors, conditions of extraction. In tea tree essential oil, 1,8-cineol
and terpinen-4-ol are the highest contents (50.29% and 20.97% respectively), while
in betel, eugenol, 4-allyl-1,2-diacetoxybenzene, and acetyl eugenol have the highest
contents (38.28%, 19.44%, and 16.67% respectively). Antioxidant and antibacterial
activity of betel is stronger than tea tree. All parameters of gel formulations such as
physical appearance, pH or viscosity are good and tantamount to commercial gels,
especially gel formulation F2 (1:2 ratio of tea tree and betel) was shown the greatest
effect in both antioxidant (IC50 at 118.70 ± 0.25μg/ml) and antibacterial activity (9.70
± 0.30 mm against S. aureus and 7.60 ± 0.17 mm against E. coli). The results
collected from this study were indicated that herbs and medicinal plants are potential
sources of antibacterial and antioxidant capacity and they can be popularly applied in
the cosmetic field. | en_US |
