| dc.description.abstract | The most advanced material for biomedical implant is the Ti-6Al-4V. However,
there are still problems with the tissue-implant contact. The most prominent disadvantage
of Ti implants, which has been insufficiently received in-depth studies, is the
biocompatibility on in vivo animal model. In this study, the implants, which have been
already manufactured by additive manufacturing methodology applying the SLM
technique (Ti-SLM) and then coated with PCD (Ti-SLM-PCD), are investigated on in vivo
rabbit model. The characterization of Ti implants provides the basic understanding of their
behaviors to evaluate the biocompatibility and osseointegration potential. Subsequently,
the CBC is conducted to assess the toxicity of the inserted implants. Then, the measurement
of biomechanical strength and histological staining are performed to assess the boneimplant binding and histological status of bone regeneration. The CBC result shows no
signs of toxicity, and the measurement of biomechanical strength reveals the highly
significant enhancement of bone-implant binding. The histological analysis indicates the
morphologically and structurally healthy condition of freshly-formed bone tissues. The
treatment of Ti implants for the tibia bone defect is a promising approach at in vivo
experimental level. | en_US |
