| dc.description.abstract | Colitis is prevalent and burdensome due to IBD. However, the treatment
method's usage of anti-inflammatory medicines has major drawbacks. Most long-term
anti-inflammatory medications are poorly absorbed and bioavailable. Thus, drugs lose
potency and worsen side effects. In this research suggests a medication delivery
technique for treating IDB or for oral medicine and treatment delivery. EPN was created
by cold gelation and homogenization by the self-assembled protein method, then used
to transport curcumin and generate a polyelectrolyte-based nanosystem named
Cur@EPN(P). This nanosystem is ideal for oral medication delivery and regulated
release due to its pH-sensitivity. Cur@EPN(P) was tested for antioxidant, antiinflammatory, and cytotoxic effects. EPN and Cur@EPN(P) were synthesized with
particle sizes of 100 and 220 nm and positive potential. EPN loading curcumin
enhances solubility, noncytotoxicity, and anti-inflammatory, free radical scavenging,
and reducing power. In a RAW 264.7 macrophage cell culture treated with LPS,
Cur@EPN(P) depletes nitric oxide to reduce inflammation. TMC and Alginate surface
modification improved stability and release at neutral pH. | en_US |
