Researching The Effect Of Low-Level Laser Therapy In Reducing The Deposition Of Uric Acid In The Body

Abstract

Objective: Uric acid (UA) is considered a risk factor for the development of numerous diseases, particularly gout, through the crystallisation of monosodium urate (MSU). There are several treatments available for disorders caused by monosodium urate crystals, but lowlevel laser therapy is emerging as non-invasive and effective. This research aims to evaluate the effect of low-level laser therapy on reducing the deposition of uric acid in a model mimicking the monosodium urate crystal in the human body. Method: The optical system utilises a continuous light source of red light (650 nm) and infrared light (780 nm and 830 nm) (5 mW, 5 V) to interact with synthetic monosodium urate crystals (7 mg/dL) that are suspended in PBS solution (pH 7.4, flow at 40 cm/s, 37 degrees Celcius). The exposure times were from 0 to 25 minutes, with measurements in an increment of 5 minutes. The effectiveness was examined by a microscope to observe the quantity of synthetic monosodium urate crystals in the investigated samples. Result: The results show good performances that the quantity of synthetic monosodium urate crystals is reduced when lasing by a low-level laser. The wavelength of 650 nm showed the highest efficiency in reducing urate crystals, with the best exposure time presented at the 25th minute. Conclusion: The effectiveness of laser therapy in reducing the deposition of uric acid promotes a non-invasive approach for treating the side effects of uric acid in the body.